Cornell College researchers have recognized a brand new approach to harness the antioxidant and antibacterial properties of a botanical compound to make nanofiber-coated cotton bandages that combat an infection and assist wounds heal extra rapidly.
The findings are particularly essential given the growing prevalence of multidrug-resistant micro organism.
Cotton gauze is among the commonest wound dressings; it is cheap, available, comfy and biocompatible. Nonetheless, it would not promote therapeutic or combat an infection.
“Cotton alone can not present a solution for these problems – it must be biofunctionalized,” stated lead writer Mohsen Alishahi, a doctoral scholar in fiber science who works within the NanoFibers and NanoTextiles (NanoFibTex) Laboratory.
Tamer Uyar, affiliate professor and the lab’s director, stated one in every of its principal analysis pursuits is creating useful fibers from sustainable supplies and exploring their potential purposes in medical textiles and drug supply techniques.
Researchers used lawsone, a red-orange compound present in henna leaves that has antioxidant, anti-inflammatory and antimicrobial properties, to spice up the efficiency of cotton.
The experimental dressing had wonderful antibacterial efficiency towards gram-negative and gram-positive bacterial species, and successfully eradicated E. coli and staph micro organism in testing.
The extended overuse of artificial antibiotics in excessive concentrations has contributed to the rise of the lethal epidemic of multidrug-resistant microbes. So the usage of pure and potent anti-bacterials similar to lawsone could function an alternative choice to artificial anti-bacterials.”
Tamer Uyar, Affiliate Professor, Cornell College
“Wound dressings ought to present an acceptable setting for facilitating therapeutic and stopping an infection,” Alishahi stated. “Utilizing completely pure supplies similar to cotton, cyclodextrin and lawsone, this dressing can facilitate each because it has complete antioxidant and anti-bacterial exercise.”
Alishahi stated that the dressing could be significantly useful for power wounds which are extremely prone to an infection, like diabetic ulcers and burns. The antioxidant and anti inflammatory properties would additionally profit extra routine wounds by decreasing the formation of scars.
This analysis was funded by Cotton Included.
Alishahi, M., et al. (2024). Functionalization of cotton nonwoven with cyclodextrin/lawsone inclusion advanced nanofibrous coating for antibacterial wound dressing. Worldwide Journal of Pharmaceutics. doi.org/10.1016/j.ijpharm.2024.123815.